Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Dmrt3em1(cre)Kldr
Name:	doublesex and mab-3 related transcription factor 3; endonuclease-mediated mutation 1, Klas Kullander
MGI ID:	MGI:6331094
Synonyms:	Dmrt3Cre
Gene:	Dmrt3  Location: Chr19:25587665-25601285 bp, + strand  Genetic Position: Chr19, 20.5 cM
Alliance:	Dmrt3em1(cre)Kldr page

Strain of Origin:

B6D2F1

Allele Type:    Endonuclease-mediated (Recombinase) Mutation:    Insertion   Dmrt3em1(cre)Kldr expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Dmrt3 (MGI:2449470)   Mutation details: Zinc finger nuclease mRNAs designed for the Dmrt3 locus, and a donor vector carrying iCre and 2A peptide sequence were introduced to B6D2F1 zygotes by pronuclear microinjection. The 2A peptide coding sequence allows for cotranslation of the Dmrt3 promoter-driven iCre followed by Dmrt3. (J:273477)

Activity:	Tissue activity of this recombinase allele
Driver:	Dmrt3 (mouse) Summary of all recombinase alleles driven by Dmrt3. Comparative matrix view of recombinase activities Alliance mouse Dmrt3 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dmrt3 Mutation:	12 strains or lines available

Original:	J:273477 Perry S, et al., Characterization of Dmrt3-Derived Neurons Suggest a Role within Locomotor Circuits. J Neurosci. 2019 Mar 6;39(10):1771-1782
All:	3 reference(s)