Summary | Mutation origin | Mutation description | Recombinase activity | Tumor data | Find Mice (IMSR) | References

Symbol:	Defa4tm1.1(cre)Fya
Name:	defensin, alpha, 4; targeted mutation 1.1, Felix Yarovinsky
MGI ID:	MGI:6331073
Synonyms:	aDefensin-4-IRES-Cre
Gene:	Defa4  Location: unknown  Genetic Position: Chr8, Syntenic
Alliance:	Defa4tm1.1(cre)Fya page

Germline Transmission:	Earliest citation of germline transmission: J:273741
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Defa4tm1.1(cre)Fya expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Defa4 (MGI:99584)   Mutation details: The targeting vector was generated to insert Frt-flanked neo selection cassette and IRES-cre into the exon 2 of the defensin alpha 4 (Defa4) gene. Resulting mice were crossed with FloO deleter to remove the neo selection cassette. Cre expression is restricted in Paneth cell in the intestines. (J:273741)

Activity:	Tissue activity of this recombinase allele
Driver:	Defa4 (mouse) Summary of all recombinase alleles driven by Defa4. Alliance mouse Defa4 gene page

List all tumor models in MMHCdb carrying Defa4tm1.1(cre)Fya

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Defa4 Mutation:	0 strains or lines available

Original:	J:273741 Burger E, et al., Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation. Cell Host Microbe. 2018 Feb 14;23(2):177-190.e4
All:	4 reference(s)