Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Scxtm1.1(cre)Shuk
Name:	scleraxis scleraxis bHLH transcription factor; targeted mutation 1.1, Chisa Shukunami
MGI ID:	MGI:6330742
Synonyms:	ScxCre KI
Gene:	Scx  Location: Chr15:76341652-76343658 bp, + strand  Genetic Position: Chr15, 35.92 cM
Alliance:	Scxtm1.1(cre)Shuk page

Germline Transmission:	Earliest citation of germline transmission: J:274387
Parent Cell Line:	KY1.1 (ES Cell)
Strain of Origin:	(C57BL/6J x 129S6/SvEvTac)F1

Allele Type:    Targeted (Null/knockout, Recombinase) Mutations:    Insertion, Intragenic deletion   Scxtm1.1(cre)Shuk expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Scx (MGI:102934)   Mutation details: The targeting vector was designed to inser Cre, along with a translational stop codon followed by FRT-flanked PGK-Neo cassette inframe after the ATG codon of Scx coding region to replace most of the Scx exon 1. The Neo cassette was removed by crossing with FLPe mice. (J:274387)

Activity:	Tissue activity of this recombinase allele
Driver:	Scx (mouse) Summary of all recombinase alleles driven by Scx. Comparative matrix view of recombinase activities Alliance mouse Scx gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scx Mutation:	12 strains or lines available

Original:	J:274387 Yoshimoto Y, et al., Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system. Sci Rep. 2017 Mar 22;7:45010
All:	2 reference(s)