About   Help   FAQ
Clec4ftm2.1(icre)Ciphe
Targeted Allele Detail
Summary
Symbol: Clec4ftm2.1(icre)Ciphe
Name: C-type lectin domain family 4, member f; targeted mutation 2.1, Centre d'ImmunoPhenomique
MGI ID: MGI:6330738
Synonyms: B6-Clec4fm2Ciphe, Clec4f-cre, Clec4f-IRES-iCRE, Clec4ftm1.1(icre)Ciphe
Gene: Clec4f  Location: Chr6:83621524-83633098 bp, - strand  Genetic Position: Chr6, 35.94 cM
Alliance: Clec4ftm2.1(icre)Ciphe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:274437
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Clec4ftm2.1(icre)Ciphe expression driven by 1 gene
 
Mutation detailsAn IRES-iCRE-loxP-Cre-NeoR-loxP cassette was introduced in the 3' untranslated region of the Clec4f gene, downstream of the stop codon by homologous recombination. Germline transmission led to the self-excision of the loxP-Cre-NeoR-loxP cassette in male germinal cells. (J:274437)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Clec4f (mouse)
Summary of all recombinase alleles driven by Clec4f.
 

Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clec4f Mutation:  28 strains or lines available
References
Original:  J:274437 Scott CL, et al., The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages. Immunity. 2018 Aug 21;49(2):312-325.e5
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory