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Gene Expression Data
Assay Details
Assay
Reference: J:85739 Rice R, et al., Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. Dev Biol. 2003 Oct 1;262(1):75-87
Assay type: RNA in situ
MGI Accession ID: MGI:6324515
Gene symbol: Alx4
Gene name: aristaless-like homeobox 4
Probe: Alx4 probe2
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 4S: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: chondrocranium pre-cartilage condensation Present Regionally restricted 4S Expression in condensations of calvarial bones and in osteogenic mesenchyme.
TS21: meninges Present 4S Expression in developing meninges.
Specimen 4T: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: chondrocranium pre-cartilage condensation Present Regionally restricted 4T Expression in condensations of calvarial bones and in osteogenic mesenchyme.
Specimen 4U: embryonic day 13.5; Foxc1ch/Foxc1ch (more )
Structure Level Pattern Image Note
TS21: chondrocranium pre-cartilage condensation Present Regionally restricted 4U Expression in condensation of calvarial bones.
TS21: head mesenchyme Weak Regionally restricted 4U Expression greatly reduced in calvarial mesenchyme.
Specimen 4V: embryonic day 13.5; Foxc1ch/Foxc1ch (more )
Structure Level Pattern Image Note
TS21: chondrocranium pre-cartilage condensation Present Regionally restricted 4V Expression in condensation of calvarial bones.
Specimen 4W: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: chondrocranium cartilage condensation Present Regionally restricted 4W Expression in condensations of calvarial bones and in osteogenic mesenchyme.
TS23: meninges Present 4W Expression in developing meninges.
Specimen 4X: embryonic day 15.5; Foxc1ch/Foxc1ch (more )
Structure Level Pattern Image Note
TS23: chondrocranium cartilage condensation Present Regionally restricted 4X Expression in condensation of calvarial bones.
TS23: head mesenchyme Weak Regionally restricted 4X Expression greatly reduced in calvarial mesenchyme.
TS23: meninges Weak Regionally restricted 4X Meningeal expression limited to inferior regions.
Specimen mutant not shown: embryonic day 15.5; Foxc1ch/Foxc1ch (more )
Structure Level Pattern Image Note
TS23: craniocervical region bone Present Authors report other craniofacial structures exhibited normal expression pattern in mutant tissue.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory