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Gene Expression Data
Assay Details
Assay
Reference: J:276701 Cui R, et al., Expression of the heparin-binding growth factors Midkine and pleiotrophin during ocular development. Gene Expr Patterns. 2019 Jun;32:28-37
Assay type: RNA in situ
MGI Accession ID: MGI:6324228
Gene symbol: Mdk
Gene name: midkine
Probe: Mdk probe3
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: eye mesenchyme Strong Regionally restricted 2A Robust expression in periocular mesenchyme.
TS17: eye surface ectoderm Strong 2A
TS17: lens vesicle Strong 2A
TS17: optic cup Strong 2A
Specimen 2B: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: eye Strong Regionally restricted 2B
TS22: perioptic mesenchyme Strong Regionally restricted 2B
TS22: cornea stroma Weak 2B
TS22: lens epithelium Weak 2B
Specimen 2C: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: eye Present Regionally restricted 2C Authors report simlar pattern of expression at a diminished levels at E16.5.
TS24: presumptive iris Strong Regionally restricted 2C Strong expression in presumptive iris stroma.
Specimen 4A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: eye posterior segment Present Regionally restricted 4A Expression in posterior ocular mesenchyme.
TS21: neural retina Present Regionally restricted 4A Expression in outer neuroblastic layer of neural retina.
TS21: optic nerve Ambiguous 4A Authors report negligible expression in the optic nerve.
Specimen 4B: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: eye Present 4B
Specimen 4C: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: retina outer nuclear layer Present 4C
TS24: retina inner nuclear layer Weak 4C
Specimen 4D: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: retina inner nuclear layer Present 4D
Specimen 4E: postnatal day 12 (more )
Structure Level Pattern Image Note
TS28: retina Absent 4E
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory