Tg(KRT14-Ctnnb1/Esr1*)D2Fmw
Transgene Detail
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| Symbol: |
Tg(KRT14-Ctnnb1/Esr1*)D2Fmw |
| Name: |
transgene insertion D2, Fiona M Watt |
| MGI ID: |
MGI:6315261 |
| Synonyms: |
Tg(K14deltaNbeta-cateninER)D2Fmw |
| Transgene: |
Tg(KRT14-Ctnnb1/Esr1*)D2Fmw Location: unknown
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| Alliance: |
Tg(KRT14-Ctnnb1/Esr1*)D2Fmw page
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| Transgene Type: |
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Transgenic (Inducible, Inserted expressed sequence) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Mutation details: The human promoter, rabbit beta-globin 5' UTR and KRT14 3'UTR drive expression of an N-terminally truncated mouse cDNA (nucleotides 715-2604) with an inducible mutant murine estrogen receptor in the basal layer of the epidermis, the outer root sheath of the hair follicle and the oral epithelium. Lines 3953 (one copy), C5 (18 copies), D2 (12 copies) and D4 (21 copies) were generated.
(J:90191)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:90191 Celso CL, et al., Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development. 2004 Apr;131(8):1787-99 |
| All: |
5 reference(s) |
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Analysis Tools
