Tg(Ins1-Rps6kb1*)1Ebm
Transgene Detail
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| Symbol: |
Tg(Ins1-Rps6kb1*)1Ebm |
| Name: |
transgene insertion 1, Ernesto Bernal-Mizrachi |
| MGI ID: |
MGI:6314786 |
| Synonyms: |
S6KCARIP |
| Transgene: |
Tg(Ins1-Rps6kb1*)1Ebm Location: unknown
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| Alliance: |
Tg(Ins1-Rps6kb1*)1Ebm page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Constitutively active, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: A mutant form of Rps6kb1, containing a deletion of amino acids 246, truncation of carboxy-terminal 104 amino acids, and threonine to glutamatic acid mutation at position 412 (p70S6K D246/DCT104 T412E) is expressed from this construct under the control of a rat insulin I promoter. This mutant protein confers rapamycin resistance and increases in basal activity in transfected cells. Three mouse lines were generated, but only one line was studied further.
(J:169347)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:169347 Elghazi L, et al., Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells. Diabetes. 2010 Oct;59(10):2390-9 |
| All: |
3 reference(s) |
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Analysis Tools
