Col4a1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:253196 Dubail J, et al., Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome. Sci Rep. 2016 Sep 30;6:33974
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6313392
Gene symbol:	Col4a1
Gene name:	collagen, type IV, alpha 1

Antibody:	anti-collagen IV
Detection system:	Alexa Fluor 568

Results

3c E16.5 +/+ (left) ©

Specimen 3c E16.5 +/+ (left): embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: lens capsule	Present		3c E16.5 +/+ (left)
TS24: tunica vasculosa lentis	Present		3c E16.5 +/+ (left)	Authors report similar expression in both genotypes.

3c E16.5 +/+ (right) ©

Specimen 3c E16.5 +/+ (right): embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: lens capsule	Present		3c E16.5 +/+ (right)

3c E16.5 del/+ (left) ©

Specimen 3c E16.5 del/+ (left): embryonic day 16.5; Adamts9^tm1.2Apte/Adamts9⁺ (more

)

Structure	Level	Pattern	Image	Note
TS24: lens capsule	Weak		3c E16.5 del/+ (left)	Reduced intensity of expression in lens capsule, most evident at E16.5.
TS24: tunica vasculosa lentis	Present		3c E16.5 del/+ (left)	Authors report similar expression in both genotypes.

3c E16.5 del/+ (right) ©

Specimen 3c E16.5 del/+ (right): embryonic day 16.5; Adamts9^tm1.2Apte/Adamts9⁺ (more

)

Structure	Level	Pattern	Image	Note
TS24: lens capsule	Weak	Regionally restricted	3c E16.5 del/+ (right)	Authors report segmentally weaker or discontinuous expression, suggestive of fenestrae.

3c P0 +/+ (left) ©

Specimen 3c P0 +/+ (left): postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: lens capsule	Present		3c P0 +/+ (left)
TS27: tunica vasculosa lentis	Present		3c P0 +/+ (left)	Authors report similar expression in both genotypes.

3c P0 +/+ (right) ©

Specimen 3c P0 +/+ (right): postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: lens capsule	Present		3c P0 +/+ (right)

3c P0 del/+ (left) ©

Specimen 3c P0 del/+ (left): postnatal day 0; Adamts9^tm1.2Apte/Adamts9⁺ (more

)

Structure	Level	Pattern	Image	Note
TS27: lens capsule	Present		3c P0 del/+ (left)	Authors report segmentally weaker or discontinuous expression, suggestive of fenestrae.

3c P0 del/+ (right) ©

Specimen 3c P0 del/+ (right): postnatal day 0; Adamts9^tm1.2Apte/Adamts9⁺ (more

)

Structure	Level	Pattern	Image	Note
TS27: lens capsule	Weak	Regionally restricted	3c P0 del/+ (right)	Authors report segmentally weaker or discontinuous expression, suggestive of fenestrae.

3c P21 +/+ ©

Specimen 3c P21 +/+: postnatal day 21 (more

)

Structure	Level	Pattern	Image	Note
TS28: lens capsule	Present		3c P21 +/+

3c P21 del/+ ©

Specimen 3c P21 del/+: postnatal day 21; Adamts9^tm1.2Apte/Adamts9⁺ (more

)

Structure	Level	Pattern	Image	Note
TS28: lens capsule	Weak		3c P21 del/+	Reduced intensity of expression in lens capsule.

5b E16.5 +/+ ©

Specimen 5b E16.5 +/+: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: lens epithelium	Present		5b E16.5 +/+

5b E16.5 del/+ ©

Specimen 5b E16.5 del/+: embryonic day 16.5; Adamts9^tm1.2Apte/Adamts9⁺ (more

)

Structure	Level	Pattern	Image	Note
TS24: lens epithelium	Weak	Regionally restricted	5b E16.5 del/+	Authors report weak expression associated with a disorganized lens epithelium.

5b P0 +/+ ©

Specimen 5b P0 +/+: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: lens epithelium	Present		5b P0 +/+

5b P0 del/+ ©

Specimen 5b P0 del/+: postnatal day 0; Adamts9^tm1.2Apte/Adamts9⁺ (more

)

Structure	Level	Pattern	Image	Note
TS27: eye anterior segment	Present	Regionally restricted	5b P0 del/+	Authors report aberrant nests of cells surrounded by expression in extracellular matrix.

5b P21 +/+ ©

Specimen 5b P21 +/+: postnatal day 21 (more

)

Structure	Level	Pattern	Image	Note
TS28: eye anterior segment	Ambiguous		5b P21 +/+

5b P21 del/+ ©

Specimen 5b P21 del+: postnatal day 21; Adamts9^tm1.2Apte/Adamts9⁺ (more

)

Structure	Level	Pattern	Image	Note
TS28: eye anterior segment	Present	Regionally restricted	5b P21 del/+	Authors report aberrant nests of cells surrounded by expression in extracellular matrix.

Specimen 5b P21 del/+ (inset): postnatal day 21; Adamts9^tm1.2Apte/Adamts9⁺ (more

)

Structure	Level	Pattern	Image	Note
TS28: eye anterior segment	Present	Regionally restricted	5b P21 del/+ (inset)	Authors report aberrant nests of cells surrounded by expression in extracellular matrix.

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