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Gene Expression Data
Assay Details
Assay
Reference: J:225741 Kanady JD, et al., Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling. Dev Biol. 2015 Sep 1;405(1):33-46
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6306301
Gene symbol: Flt4
Gene name: FMS-like tyrosine kinase 4
Results
Specimen 4A/C: embryonic day 18.5 (more )
Note: Double labeled: magenta - Vegfr3 (Flt4); green - Cx37 (Gja4 assay MGI:6306302),
Structure Level Pattern Image Note
TS26: small intestine Present Regionally restricted 4A , 4C Expression in submucosal lymphatics of small intestine.

Specimen 4D/F: embryonic day 18.5 (more )
Note: Double labeled: magenta - Vegfr3 (Flt4); green - Cx37 (Gja4 assay MGI:6306302),
Structure Level Pattern Image Note
TS26: small intestine Present Regionally restricted 4D , 4F Expression in submucosal lymphatics of small intestine.

Specimen 4G/I: embryonic day 18.5 (more )
Note: Double labeled: magenta - Vegfr3 (Flt4); green - Cx37 (Gja4 assay MGI:6306302),
Structure Level Pattern Image Note
TS26: colon Present Regionally restricted 4I , 4G Expression in submucosal lymphatics of colon.

Specimen 4J/L: embryonic day 18.5 (more )
Note: Double labeled: magenta - Vegfr3 (Flt4); green - Cx37 (Gja4 assay MGI:6306302),
Structure Level Pattern Image Note
TS26: colon Present Regionally restricted 4L , 4J Expression in submucosal lymphatics of colon.

Specimen 5A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: small intestine Present Regionally restricted 5A Expression in submucosal lymphatics.

Specimen 5B: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: colon Present Regionally restricted 5B Expression in submucosal lymphatics.

Specimen 5C: embryonic day 18.5; Foxc2tm1Miu/Foxc2+ (more )
Structure Level Pattern Image Note
TS26: small intestine Present Regionally restricted 5C Expression in submucosal lymphatics.

Specimen 5D: embryonic day 18.5; Foxc2tm1Miu/Foxc2+ (more )
Structure Level Pattern Image Note
TS26: colon Present Regionally restricted 5D Expression in submucosal lymphatics.

Specimen 5E: embryonic day 18.5; Gja4tm1Paul/Gja4tm1Paul (more )
Structure Level Pattern Image Note
TS26: small intestine Present Regionally restricted 5E Expression in submucosal lymphatics.

Specimen 5F: embryonic day 18.5; Gja4tm1Paul/Gja4tm1Paul (more )
Structure Level Pattern Image Note
TS26: colon Present Regionally restricted 5F Expression in submucosal lymphatics.

Specimen 5G: embryonic day 18.5; Foxc2tm1Miu/Foxc2+, Gja4tm1Paul/Gja4tm1Paul (more )
Structure Level Pattern Image Note
TS26: small intestine Present Regionally restricted 5G Authors state that submucosal lymph vessel diameter and area density of double mutant mice were significantly greater, and length density and branch point density were significantly lower, than WT or single mutant mice.

Specimen 5H: embryonic day 18.5; Foxc2tm1Miu/Foxc2+, Gja4tm1Paul/Gja4tm1Paul (more )
Structure Level Pattern Image Note
TS26: colon Present Regionally restricted 5H Authors state that submucosal lymph vessel diameter and area density of double mutant mice were significantly greater, and length density and branch point density were significantly lower, than WT or single mutant mice.

Specimen 6A,B,C: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: small intestine Present Regionally restricted 6C , 6A , 6B Expression in submucosal lymphatics and lacteals of proximal small intestine.

Specimen 6D,E,F: embryonic day 18.5; Foxc2tm1Miu/Foxc2+ (more )
Structure Level Pattern Image Note
TS26: small intestine Present Regionally restricted 6F , 6D , 6E Expression in submucosal lymphatics and lacteals of proximal small intestine.

Specimen 6G,H,I: embryonic day 18.5; Gja4tm1Paul/Gja4tm1Paul (more )
Structure Level Pattern Image Note
TS26: small intestine Present Regionally restricted 6H , 6G , 6I Expression in submucosal lymphatics and lacteals of proximal small intestine.

Specimen 6J,K,L: embryonic day 18.5; Foxc2tm1Miu/Foxc2+, Gja4tm1Paul/Gja4tm1Paul (more )
Structure Level Pattern Image Note
TS26: small intestine Present Regionally restricted 6L , 6J , 6K Authors state that lacteals of double mutant mice were significantly shorter than WT or single mutant mice.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory