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Tg(Myh6-cat)MEF2MUTARbns
Transgene Detail
Summary
Symbol: Tg(Myh6-cat)MEF2MUTARbns
Name: transgene insertion MEF2MUTA, Jeffrey Robbins
MGI ID: MGI:6305402
Transgene: Tg(Myh6-cat)MEF2MUTARbns  Location: unknown  
Alliance: Tg(Myh6-cat)MEF2MUTARbns page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
 
Mutation details: The transgene construct used for the Tg(Myh6-cat)7Rbns and Tg(Myh6-cat)27Rbns alleles was modified to inactivate the Mef2a binding site located at -327..-314 (relative to the transcription start site). Using site-directed mutagenesis, wildtype binding site TTAAAAATAACTGA was changed to TGACCACTCCATGC. (J:4164)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:4164 Adolph EA, et al., Role of myocyte-specific enhancer-binding factor (MEF-2) in transcriptional regulation of the alpha-cardiac myosin heavy chain gene. J Biol Chem. 1993 Mar 15;268(8):5349-52
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory