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Gene Expression Data
Assay Details
Assay
Reference: J:188806 Hurd EA, et al., Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice. Mech Dev. 2012 Sep;129(9-12):308-23
Assay type: RNA in situ
MGI Accession ID: MGI:6305183
Gene symbol: Ntn1
Gene name: netrin 1
Probe: Ntn1 probe1
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 6B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: semicircular canal Present Regionally restricted 6B Expression was detected in a medial domain of the developing posterior semicircular canal and a lateral domain within the posterior/lateral semicircular canal.
Specimen 6C: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7+ (more )
Structure Level Pattern Image Note
TS19: semicircular canal Present Regionally restricted 6C The medial expression domain was absent from the posterior semicircular canal epithelium at E11.5.
Specimen 6D: embryonic day 11.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: semicircular canal Present Regionally restricted 6D The medial expression domain was absent from the posterior semicircular canal epithelium at E11.5.
Specimen 6E: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: semicircular canal Weak Regionally restricted 6E The entire expression domain was reduced in the conditional mutant.
Specimen 6G: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: semicircular canal Present Regionally restricted 6G Expression was detected in a medial domain of the developing posterior semicircular canal and a lateral domain within the posterior/lateral semicircular canal.
Specimen 6H: embryonic day 12.5; Chd7Gt(S20-7E1)Sor/Chd7+ (more )
Structure Level Pattern Image Note
TS20: semicircular canal Present 6H
Specimen 6I: embryonic day 12.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: semicircular canal Present 6I
Specimen 6J: embryonic day 12.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: semicircular canal Weak Regionally restricted 6J The entire expression domain was reduced in the conditional mutant.
Specimen Table 1 +/+ E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: inner ear Present
Specimen Table 1 Gt/+ E11.5: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7+ (more )
Structure Level Pattern Image Note
TS19: inner ear Ambiguous Expression was delayed.
Specimen Table 1 Cond. het E11.5: embryonic day 11.5; Chd7tm1.1Dmm/Chd7+, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: inner ear Ambiguous Expression was delayed.
Specimen Table 1 CKO E11.5: embryonic day 11.5; Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: inner ear Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory