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Gene Expression Data
Assay Details
Assay
Reference: J:149237 Perez-Balaguer A, et al., Shh dependent and independent maintenance of basal midbrain. Mech Dev. 2009 May-Jun;126(5-6):301-13
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6304456
Gene symbol: Nkx2-2
Gene name: NK2 homeobox 2
Antibody: 74.5A5
Results
Specimen 6B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: midbrain lateral wall Present Regionally restricted 6B Immunopositive cells were detected in a wide band at the most dorsal aspect of the basal plate.
Specimen 6E: embryonic day 10.5; Shhtm2Amc/Shhtm2Amc, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: midbrain lateral wall Present Regionally restricted 6E At E10.5 the wide band of the expression was missing. However, a small patch of positive cells was detected in the early mantle layer of the conditional mutant.
Specimen 6H: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: midbrain lateral wall Present Regionally restricted 6H Expression was refined in a narrow band extending from the ventricular to the pial surface ventral to the alar-basal boundary.
TS20: midbrain mantle layer Present Regionally restricted 6H A positive patch of cells was also found in the alar mantle layer.
Specimen 6K: embryonic day 12.5; Shhtm2Amc/Shhtm2Amc, En1tm2(cre)Wrst/En1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: midbrain mantle layer Present Regionally restricted 6K A small patch of immunopositive cells remains in the mantle layer of the conditional mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory