About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:47986 Dellovade TL, et al., The gonadotropin-releasing hormone system does not develop in Small-Eye (Sey) mouse phenotype. Brain Res Dev Brain Res. 1998 May 15;107(2):233-40
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6303851
Gene symbol: Gnrh1
Gene name: gonadotropin releasing hormone 1
Antibody: LR1
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen not shown: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: olfactory epithelium Present
TS21: nasal septum Present Expression was detected in migrating cells along the nasal septum in close association with Ncam1-immunoreactive fibers.

Specimen 1A: embryonic day 14.5 (more )
Note: Double labeled: red/brown - Gnrh1; blue/gray - Ncam1 (assay MGI:6303885).
Structure Level Pattern Image Note
TS22: nasal septum Present Regionally restricted 1A , 1B Expression was detected in migrating cells along the nasal septum in close association with Ncam1-immunoreactive fibers.
TS22: main olfactory bulb Present Regionally restricted 1A Expression was detected in the caudal region of the olfactory bulb.
TS22: olfactory epithelium Present 1A
TS22: brain ventricular layer Absent 1A
TS22: midbrain Absent 1A
TS22: tectum Absent 1A

Specimen not shown: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: forebrain Present Regionally restricted Thick immunoreactive cords were entering the forebrain.

Specimen 1C: embryonic day 16.5 (more )
Note: Double labeled: red/brown - Gnrh1; blue/gray - Ncam1 (assay MGI:6303885).
Structure Level Pattern Image Note
TS24: forebrain Present Regionally restricted 1C Thick immunoreactive cords were entering the forebrain medial and caudal to the olfactory bulbs.
TS24: nasal septum Present Regionally restricted 1C Immunoreactive cells were seen migrating along the nasal septum.
TS24: brain ventricular layer Absent 1C
TS24: midbrain Absent 1C
TS24: tectum Absent 1C

Specimen 1E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: forebrain Present 1E
TS26: hypothalamus Present 1E
TS26: median eminence Present 1E

Specimen not shown: embryonic day 13.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS21: nose Absent

Specimen 2A: embryonic day 14.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS22: forebrain Absent 2A
TS22: midbrain Absent 2A
TS22: nose Absent 2A
TS22: tectum Absent 2A

Specimen 2B: embryonic day 16.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS24: forebrain Absent 2B
TS24: midbrain Absent 2B
TS24: nose Absent 2B
TS24: tectum Absent 2B

Specimen 2C: embryonic day 18.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS26: forebrain Absent 2C
TS26: midbrain Absent 2C
TS26: nose Absent 2C
TS26: tectum Absent 2C

Specimen 2D: embryonic day 18.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS26: hypothalamus Absent 2D

Specimen 3 E13 wt: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: nasal septum Present
TS21: olfactory epithelium Present
TS21: forebrain Present Regionally restricted Expression was in cells traversing from the periphery into the developing forebrain.

Specimen 3 E13 Sey/+: embryonic day 13.5; Pax6Sey/Pax6+ (more )
Structure Level Pattern Image Note
TS21: nasal septum Present Expression was similar to wild type.
TS21: olfactory epithelium Present Expression was similar to wild type.
TS21: forebrain Present Regionally restricted Expression was in cells traversing from the periphery into the developing forebrain as in wild type.

Specimen 3 E15 wt: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: forebrain Present
TS23: nasal septum Present
TS23: olfactory epithelium Present

Specimen 3 E15 Sey/+: embryonic day 15.5; Pax6Sey/Pax6+ (more )
Structure Level Pattern Image Note
TS23: forebrain Present Expression was similar to wild type.
TS23: nasal septum Present Expression was similar to wild type.
TS23: olfactory epithelium Present Expression was similar to wild type.

Specimen 3 E18 wt: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: forebrain Present
TS26: nasal septum Present
TS26: olfactory epithelium Present

Specimen 3 E18 Sey/+: embryonic day 18.5; Pax6Sey/Pax6+ (more )
Structure Level Pattern Image Note
TS26: forebrain Present Expression was similar to wild type.
TS26: nasal septum Present Expression was similar to wild type.
TS26: olfactory epithelium Present Expression was similar to wild type.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory