Fgf10tm2.1(cre/ERT2)Sbel
Targeted Allele Detail
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Symbol: |
Fgf10tm2.1(cre/ERT2)Sbel |
Name: |
fibroblast growth factor 10; targeted mutation 2.1, Saverio Bellusci |
MGI ID: |
MGI:6296741 |
Synonyms: |
Fgf10Cre-ERT2, Fgf10Ki-v2, Fgf10tm2(eYFP-Cre/ERT2)Sbel |
Gene: |
Fgf10 Location: Chr13:118851199-118928651 bp, + strand Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
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Alliance: |
Fgf10tm2.1(cre/ERT2)Sbel page
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Germline Transmission: |
Earliest citation of germline transmission:
J:308431
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Parent Cell Line: |
Other (see notes) (ES Cell)
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Strain of Origin: |
C57BL/6NCrl
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Allele Type: |
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Targeted (Inducible, Null/knockout, Recombinase, Reporter) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Fgf10tm2.1(cre/ERT2)Sbel expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: An EGFP gene and inducible cre/ERT2 fusion were inserted into the 3' UTR immediately downstream of the stop codon of the exon 3. The self-cleavage LF2A and T2A sequences will lead to 3 distinct proteins. Flp-mediated recombination removed the selection cassette. The homozygous embryos suffered from lung and limb agenesis and the analysis of Fgf10 expression by qPCR indicated a drastic reduction in Fgf10 expression. It is a loss-of-function allele.
(J:308431)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Fgf10
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fgf10 Mutation: |
33 strains or lines available
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Original: |
J:308431 Chu X, et al., Validation of a Novel Fgf10 (Cre-ERT2) Knock-in Mouse Line Targeting FGF10(Pos) Cells Postnatally. Front Cell Dev Biol. 2021;9:671841 |
All: |
1 reference(s) |
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