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Gene Expression Data
Assay Details
Assay
Reference: J:24148 Mitsiadis TA, et al., Midkine (MK), a heparin-binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis. J Cell Biol. 1995 Apr;129(1):267-81
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6294285
Gene symbol: Mdk
Gene name: midkine
Antibody: anti-MK
Results
Specimen 2a: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: mandibular process Strong Regionally restricted 2a Expression is on the cell surfaces and basement membranes in the thickened epithelium.
TS19: maxillary process Strong Regionally restricted 2a Expression is on the cell surfaces and basement membranes in the thickened epithelium.
TS19: oral epithelium Strong Regionally restricted 2a Expression is on the cell surfaces and basement membranes in the thickened epithelium.
TS19: mandibular process mesenchyme Weak Punctate 2a

Specimen 2b: embryonic day 13.5 (more )
Note: Bud stage of tooth development.
Structure Level Pattern Image Note
TS21: lower jaw molar epithelium Present Regionally restricted 2b Expression is on the cell surface of the dental epithelial bud and in the basement membrane.
TS21: tooth bud Present Regionally restricted 2b Expression is on the cell surface of the dental epithelial bud and in the basement membrane.
TS21: lower jaw molar mesenchyme Present Regionally restricted 2b Expression is on the cell surface of the condensed dental mesenchyme.

Specimen 2c: embryonic day 14.5 (more )
Note: Early cap stage of tooth development.
Structure Level Pattern Image Note
TS22: lower jaw molar mesenchyme Present Regionally restricted 2c Expression is on the cell surface of the condensed dental mesenchyme.
TS22: lower jaw molar epithelium Present Regionally restricted 2c Expression is on the cell surface of the dental epithelial bud and in the basement membrane.
TS22: lower jaw Present Regionally restricted 2c Expression is in the dental epithelium and mesenchyme and is absent in surrounding tissues.
TS22: mandible Weak Regionally restricted 2c Expression is in osteogenic and chondrogenic areas.
TS22: cap stage tooth Present Regionally restricted 2c

Specimen 2d: embryonic day 16.5 (more )
Note: Early bell stage of tooth development.
Structure Level Pattern Image Note
TS24: inner enamel epithelium Present Regionally restricted 2d Expression is on the surfaces of cells of the inner dental epithelium and in the basement membrane.
TS24: lower jaw molar epithelium Present Regionally restricted 2d Expression is on the surfaces of cells of the inner dental epithelium and in the basement membrane.
TS24: lower jaw molar mesenchyme Present Regionally restricted 2d Expression is in mesenchymal cells underlying the enamel epithelium in the cuspal area.
TS24: lower jaw molar dental papilla Weak 2d
TS24: early bell stage tooth Present Regionally restricted 2d

Specimen 2e: embryonic day 18.5 (more )
Note: Bell stage of tooth development.
Structure Level Pattern Image Note
TS26: inner enamel epithelium Present Regionally restricted 2e Expression is in the inner dental epithelium (preameloblasts).
TS26: lower jaw molar enamel organ Present Regionally restricted 2e Expression is in the inner dental epithelium (preameloblasts).
TS26: lower jaw molar dental papilla Present Regionally restricted 2e Expression is in the mesenchyme and basement membrane.
TS26: lower jaw molar mesenchyme Present Regionally restricted 2e Expression is in the processes of the differentiating odontoblasts.
TS26: bell stage tooth Present Regionally restricted 2e

Specimen 2f: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: lower jaw molar dental papilla Present Regionally restricted 2f Expression is localized on the surfaces of differentiating odontoblasts and is lost from odontoblasts after terminal differentiation.
TS27: molar dental pulp Present Regionally restricted 2f Expression is in the center.
TS27: predentin Present 2f

Specimen 3b: embryonic day 15.5 (more )
Note: Cap stage of tooth development.
Structure Level Pattern Image Note
TS23: inner enamel epithelium Strong Regionally restricted 3b Expression is on the surfaces of cells of the inner dental epithelium and in the basement membrane.
TS23: lower jaw molar enamel organ Strong Regionally restricted 3b Expression is on the surfaces of cells of the inner dental epithelium and in the basement membrane.
TS23: lower jaw molar mesenchyme Weak 3b
TS23: cap stage tooth Present Regionally restricted 3b

Specimen not shown: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: oral region mesenchyme Present Regionally restricted Expression is on the surfaces of condensing mesenchymal cells in close contact with dental epithelium and is punctate in more peripheral mesenchymal cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory