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Gene Expression Data
Assay Details
Assay
Reference: J:206666 Parry DA, et al., SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid. Am J Hum Genet. 2013 Dec 5;93(6):1135-42
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6283852
Gene symbol: Gsc
Gene name: goosecoid homeobox
Antibody: anti-GSC (N-12)
Detection system: Secondary antibody
Results
Specimen 3A E11.5: embryonic day 11.5 (more )
Note: Double labeled: green - Gsc; red - Pax3 (assay MGI:6283850).
Structure Level Pattern Image Note
TS19: 1st branchial arch Present 3A E11.5 merge , 3A E11.5 Goosecoid
TS19: 1st branchial groove Present 3A E11.5 merge , 3A E11.5 Goosecoid
TS19: fronto-nasal process Present 3A E11.5 merge , 3A E11.5 Goosecoid
Specimen 3A E16.5: embryonic day 16.5 (more )
Note: Double labeled: green - Gsc; red - Pax3 (assay MGI:6283850).
Structure Level Pattern Image Note
TS24: shoulder bone Present Regionally restricted 3A E16.5 merge , 3A E16.5 Goosecoid Expression is in the bony attachment points.
Specimen 3B: embryonic day 14.5 (more )
Note: Double labeled: green - Gsc; red - Pax3 (assay MGI:6283850).
Structure Level Pattern Image Note
TS22: hip joint primordium Present 3B Goosecoid , 3B merge
TS22: pubis pre-cartilage condensation Present 3B Goosecoid , 3B merge
Specimen S2 A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: hindlimb bud Present Regionally restricted S2A There is nuclear expression in connective tissue by the fibula.
Specimen S2 B left: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindlimb bud mesenchyme Strong Regionally restricted S2B left Expression is in the condensations including the probable femoral head.
Specimen S2 B right: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: head Present Regionally restricted S2B right Expression surrounds the neural tube.
TS17: head mesenchyme derived from neural crest Present Regionally restricted S2B right Expression is in the post-otic neural crest cells surrounding the otic vesicle.
TS17: brain Absent S2B right
Specimen S2 C mandibular: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: mandibular process Strong S2C mandibular process
Specimen S2 C anterior limb: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: forelimb bud Strong S2C anterior limb bud
Specimen S2 C hindlimb: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: hindlimb bud Strong S2C hindlimb bud
Specimen S2 C ribs: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: rib pre-cartilage condensation Strong S2C ribs
Specimen S2 D hindlimb: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hindlimb Present Regionally restricted S2D hindlimb Expression is in the connective tissue and is absent in the bone primordia.
Specimen S2 D forelimb: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forelimb Present Regionally restricted S2D forelimb Expression is in the connective tissue and is absent in the bone primordia.
Specimen S2 D humerus: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: shoulder Present Regionally restricted S2D humerus Expression is in the muscles and connective tissue of the shoulder joint.
Specimen S2 D mandibular: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: mandible primordium Present S2D mandibular primordium
Specimen S3 post-otic: embryonic day 12.5 (more )
Note: Double labeled: green - Gsc; red - Pax3 (assay MGI:6283850).
Structure Level Pattern Image Note
TS20: head mesenchyme derived from neural crest Present Regionally restricted S3_post-otic Goosecoid , S3_post-otic merge Expression is in post-otic neural crest cells.
Specimen S3 nasal cavity: embryonic day 12.5 (more )
Note: Double labeled: green - Gsc; red - Pax3 (assay MGI:6283850).
Structure Level Pattern Image Note
TS20: nasal cavity Present S3_nasal cavity Goosecoid , S3_nasal cavity merge
Specimen S3 dorsal root: embryonic day 12.5 (more )
Note: Double labeled: green - Gsc; red - Pax3 (assay MGI:6283850).
Structure Level Pattern Image Note
TS20: dorsal root ganglion Present S3_dorsal root Goosecoid , S3_dorsal root merge
TS20: rib pre-cartilage condensation Present S3_dorsal root Goosecoid , S3_dorsal root merge
Specimen S3 hindlimb: embryonic day 12.5 (more )
Note: Double labeled: green - Gsc; red - Pax3 (assay MGI:6283850).
Structure Level Pattern Image Note
TS20: hindlimb Present S3_hindlimb bud merge , S3_hindlimb bud Goosecoid
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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