Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Tprnem1Bzha
Name:	taperin; endonuclease-mediated mutation 1, Bo Zhao
MGI ID:	MGI:6281115
Synonyms:	taperinIn103
Gene:	Tprn  Location: Chr2:25152630-25159897 bp, + strand  Genetic Position: Chr2, 17.11 cM
Alliance:	Tprnem1Bzha page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Insertion   Mutation details: CRISPR/Cas9 technology generated a 103 bp insertion between nucleotides 217 and 218 in exon 1. The frameshift caused by the insertion creates an early stop codon. Immunostaining shows absence of protein in stereocilia and support cells. (J:271271)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tprn Mutation:	19 strains or lines available

Original:	J:271271 Liu C, et al., GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing. Cell Rep. 2018 Oct 30;25(5):1268-1280.e4
All:	1 reference(s)