Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tie1tm1(icre/Esr1*)Hrr
Name:	tyrosine kinase with immunoglobulin-like and EGF-like domains 1; targeted mutation 1.1, Hans-Reimer Rodewald
MGI ID:	MGI:6279994
Synonyms:	Tie1MiCreM Neo, Tie1tm1(icre/Esr1*)Aug
Gene:	Tie1  Location: Chr4:118328388-118347046 bp, - strand  Genetic Position: Chr4, 54.67 cM
Alliance:	Tie1tm1(icre/Esr1*)Hrr page

Germline Transmission:	Earliest citation of germline transmission: J:250996
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tie1tm1(icre/Esr1*)Hrr expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tie1 (MGI:99906)   Mutation details: A tamoxifen-inducible codon-improved Cre recombinase (iCre) flanked by two mutated estrogen receptor sites (MeriCreMer) and FRT-flanked Neo cassette was inserted into the first exon of the Tie1 locus in embryonic stem cells to express the fusion protein MeriCreMer under the control of the endogenous Tie1 promoter. (J:250996)

Activity:	Tissue activity of this recombinase allele
Driver:	Tie1 (mouse) Summary of all recombinase alleles driven by Tie1. Alliance mouse Tie1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tie1 Mutation:	67 strains or lines available

Original:	J:250996 Savant S, et al., The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep. 2015 Sep 22;12(11):1761-73
All:	1 reference(s)