Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Kittm1(cre)Htng
Name:	KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1, Hiroki Taniguchi
MGI ID:	MGI:6279770
Synonyms:	c-kitIRES-Cre
Gene:	Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance:	Kittm1(cre)Htng page

Germline Transmission:	Earliest citation of germline transmission: J:245913
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Kittm1(cre)Htng expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Kit (MGI:96677)   Mutation details: A targeting vector containing IRES-cre coding sequence followed by a polyadenylation signal sequence, and a FRT site flanked PGK-neo cassette was inserted immediately following the stop codon in exon 21 of the targeted Kit gene. The construct was electroporated into embryonic stem (ES) cells. Chimeric mice were generated by aggregating correctly targeted ES cells by tetraploid complementation. The resulting chimeric animals were tested for germline transmission. (J:245913)

Activity:	Tissue activity of this recombinase allele
Driver:	Kit (mouse) Summary of all recombinase alleles driven by Kit. Alliance mouse Kit gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kit Mutation:	179 strains or lines available

Original:	J:245913 Amat SB, et al., Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice. PLoS One. 2017;12(6):e0179347
All:	2 reference(s)