Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(SOD1*D90A)#Mrkl
Name:	transgene insertion, Stefan L Marklund
MGI ID:	MGI:6276144
Transgene:	Tg(SOD1*D90A)#Mrkl  Location: unknown
Alliance:	Tg(SOD1*D90A)#Mrkl page

Strain of Origin:

C57BL/6 x CBA

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Undefined   Tg(SOD1*D90A)#Mrkl expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human SOD1 (6647) Sod1  (MGI:98351) mutated human gene   Mutation details: The transgene contains the complete genomic sequence of the human superoxide dismutase 1, with a mutation in exon 4 changing codon 90 from aspartate to alanine (p.D90A). This mutation is the most common mutation found in amyotrophic lateral sclerosis (ALS) patients. Founders 134 and 154 had the highest transgene copy number and were selected for further study. The pound (#) sign is used when the specific line is not specified. (J:269950)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:269950 Jonsson PA, et al., Motor neuron disease in mice expressing the wild type-like D90A mutant superoxide dismutase-1. J Neuropathol Exp Neurol. 2006 Dec;65(12):1126-36
All:	2 reference(s)