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Gene Expression Data
Assay Details
Assay
Reference: J:258535 Tan TY, et al., Monoallelic BMP2 Variants Predicted to Result in Haploinsufficiency Cause Craniofacial, Skeletal, and Cardiac Features Overlapping Those of 20p12 Deletions. Am J Hum Genet. 2017 Dec 7;101(6):985-994
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6273814
Gene symbol: Bmp2
Gene name: bone morphogenetic protein 2
Reporter: lacZ
Direct Detection
Results
Specimen S2A: embryonic day 12.5; Bmp2tm1(KOMP)Vlcg/Bmp2+ (more )
Structure Level Pattern Image Note
TS20: vibrissa follicle Strong S2A
TS20: dermis Strong Regionally restricted S2A Strong staining was noted in the facial dermis and the supraorbital dermis.
Specimen S2B: embryonic day 12.5; Bmp2tm1(KOMP)Vlcg/Bmp2+ (more )
Structure Level Pattern Image Note
TS20: Meckel's cartilage Strong S2B
TS20: oral region epithelium Strong Regionally restricted S2B Strong expression was detected in the dental epithelium.
Specimen S2C: embryonic day 12.5; Bmp2tm1(KOMP)Vlcg/Bmp2+ (more )
Structure Level Pattern Image Note
TS20: embryo Present S2C
Specimen S2D: embryonic day 12.5; Bmp2tm1(KOMP)Vlcg/Bmp2+ (more )
Structure Level Pattern Image Note
TS20: limb cartilage condensation Strong S2D
Specimen S2E: embryonic day 12.5; Bmp2tm1(KOMP)Vlcg/Bmp2+ (more )
Structure Level Pattern Image Note
TS20: rib pre-cartilage condensation Strong S2E
Specimen S2F: embryonic day 12.5; Bmp2tm1(KOMP)Vlcg/Bmp2+ (more )
Structure Level Pattern Image Note
TS20: heart Strong Regionally restricted S2F Strong expression was detected in the valves and ventricular-atrial junctions.
TS20: heart valve primordium Strong S2F
Specimen S2G: embryonic day 12.5; Bmp2tm1(KOMP)Vlcg/Bmp2+ (more )
Structure Level Pattern Image Note
TS20: rib pre-cartilage condensation Strong S2G
Specimen S2H: embryonic day 12.5; Bmp2tm1(KOMP)Vlcg/Bmp2+ (more )
Structure Level Pattern Image Note
TS20: heart Strong Regionally restricted S2H Strong expression was detected in the valves and ventricular-atrial junctions.
TS20: heart valve primordium Strong S2H
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory