Tg(Prnp-SNCA*A30P)5093Kha
Transgene Detail
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| Symbol: |
Tg(Prnp-SNCA*A30P)5093Kha |
| Name: |
transgene insertion 5093, Karen Hsiao Ashe |
| MGI ID: |
MGI:6273616 |
| Synonyms: |
Tg5093 |
| Transgene: |
Tg(Prnp-SNCA*A30P)5093Kha Location: unknown
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| Alliance: |
Tg(Prnp-SNCA*A30P)5093Kha page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Prnp-SNCA*A30P)5093Kha expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
SNCA (6622) |
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human SNCA encoding A30P mutation |
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Mutation details: A hamster PrP promoter drives expression of a mutant form of human SNCA (A30P). Two mouse lines were generated, Tg5093 and Tg5102). The highest expressing line (Tg5093) had 15-fold transgenic brain alpha-synuclein A30P expression and age-related motor dysfunction, and was characterized in detail.
(J:102796)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:102796 Gomez-Isla T, et al., Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice. Neurobiol Aging. 2003 Mar-Apr;24(2):245-58 |
| All: |
4 reference(s) |
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Analysis Tools
