Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Ripk1tm1.1Mkel
Name:	receptor (TNFRSF)-interacting serine-threonine kinase 1; targeted mutation 1.1, Michelle Kelliher
MGI ID:	MGI:6272324
Synonyms:	Ripk1D138N
Gene:	Ripk1  Location: Chr13:34186346-34221130 bp, + strand  Genetic Position: Chr13, 14.01 cM
Alliance:	Ripk1tm1.1Mkel page

Germline Transmission:	Earliest citation of germline transmission: J:241205
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Not Applicable) Mutation:    Single point mutation   Mutation details: A floxed neo cassette was inserted into intron 3 and a mutation was introduced in exon 4 creating an aspartate to aspargine substitution at position 138 (p.D138N). Cre mediated recombination removed the neo cassette. This mutation alters kinase activity of the protein. (J:241205)

In Mice Carrying this Mutation:

30 assay results 1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ripk1 Mutation:	31 strains or lines available

Original:	J:241205 Polykratis A, et al., Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo. J Immunol. 2014 Aug 15;193(4):1539-43
All:	23 reference(s)