Tjp1tm2c(KOMP)Wtsi
Targeted Allele Detail
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| Symbol: |
Tjp1tm2c(KOMP)Wtsi |
| Name: |
tight junction protein 1; targeted mutation 2c, Wellcome Trust Sanger Institute |
| MGI ID: |
MGI:6272009 |
| Synonyms: |
ZO-1fl |
| Gene: |
Tjp1 Location: Chr7:64945913-65177529 bp, - strand Genetic Position: Chr7, 35.02 cM
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| Alliance: |
Tjp1tm2c(KOMP)Wtsi page
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| IMPC: |
Tjp1 gene page |
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| Germline Transmission: |
Earliest citation of germline transmission:
J:267500
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| Parent Cell Line: |
JM8A3.N1 (ES Cell)
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| Strain of Origin: |
C57BL/6N-Atm1Brd
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| Project Collection: |
KOMP-CSD
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| Allele Type: |
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Targeted (Conditional ready) |
| Mutation: |
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Insertion
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Mutation details: The L1L2_gt0 cassette was inserted at position 64993139 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 64993923. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:267500)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tjp1 Mutation: |
67 strains or lines available
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| Original: |
J:267500 Odenwald MA, et al., The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. J Biol Chem. 2018 Nov 9;293(45):17317-17335 |
| All: |
5 reference(s) |
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Analysis Tools
