Cpt1atm1c(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Cpt1atm1c(EUCOMM)Hmgu |
Name: |
carnitine palmitoyltransferase 1a, liver; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:6268444 |
Synonyms: |
CPT1AloxP |
Gene: |
Cpt1a Location: Chr19:3372334-3435733 bp, + strand Genetic Position: Chr19, 3.08 cM
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Alliance: |
Cpt1atm1c(EUCOMM)Hmgu page
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IMPC: |
Cpt1a gene page |
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Mutant Cell Lines: |
HEPD0727_3_E10, HEPD0727_3_H09 |
Germline Transmission: |
Earliest citation of germline transmission:
J:265026
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 3405947 of Chromosome 19 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 3406754. The critical exon(s) is/are thus flanked by loxP sites.A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:265026)
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Original: |
J:265026 Mir JF, et al., Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex. Mol Neurobiol. 2018 Sep;55(9):7216-7228 |
All: |
4 reference(s) |
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