Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Ighg1em1(cre/ERT2)Rsky
Name:	immunoglobulin heavy constant gamma 1 (G1m marker); endonuclease-mediated mutation 1, Klaus Rajewsky
MGI ID:	MGI:6266867
Synonyms:	Cgamma1-CreERT2
Gene:	Ighg1  Location: Chr12:113290161-113294143 bp, - strand  Genetic Position: Chr12, 62.1 cM
Alliance:	Ighg1em1(cre/ERT2)Rsky page

Strain of Origin:

C57BL/6NCrl

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Ighg1em1(cre/ERT2)Rsky expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ighg1 (MGI:96446)   Mutation details: Single guide RNAs and a targeting vector, designed to insert an internal ribosomal entry site (IRES) followed by a cre/ERT2 fusion gene into the 3' untranslated region of the immunoglobulin heavy constant gamma 1 (Ighg1) gene, and the Cas9 nuclease were introduced into the cytoplasm of C57BL/6NCrl fertilized eggs with well recognized pronuclei. (J:267281)

Activity:	Tissue activity of this recombinase allele
Driver:	Ighg1 (mouse) Summary of all recombinase alleles driven by Ighg1. Alliance mouse Ighg1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ighg1 Mutation:	28 strains or lines available

Original:	J:267281 Weber T, et al., A novel allele for inducible Cre expression in germinal center B cells. Eur J Immunol. 2018 Oct 25;
All:	1 reference(s)