Tg(Gabra6-Bmi1)1004Mro
Transgene Detail
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| Symbol: |
Tg(Gabra6-Bmi1)1004Mro |
| Name: |
transgene insertion 1004, Silvia Marino |
| MGI ID: |
MGI:6259605 |
| Synonyms: |
Gabra6-Bmi1, Gabra6-Bmi1 founder line T4 |
| Transgene: |
Tg(Gabra6-Bmi1)1004Mro Location: unknown
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| Alliance: |
Tg(Gabra6-Bmi1)1004Mro page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Gabra6-Bmi1)1004Mro expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Bmi1 (MGI:88174) |
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Mutation details: The transgene comprises a 6-kb mouse genomic DNA fragment containing exons 1-8 of the gamma-aminobutyric acid type A receptor 6 (Gabra6) gene followed by an internal ribosomal entry site (IRES) and the full-length, 3.1-kb mouse Bmi1 polycomb ring finger oncogene (Bmi1) cDNA. Two (of four generated) transgenic lines, designated T3 and T4, overexpressed Bmi1 mRNA, as determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis, and BMI1 protein, as quantified by immunoblot analysis, in the cerebellum at both postnatal days (P) 9 and P15; the protein was localized to the internal granule cell layer by immunohistochemical labeling of the cerebella of nine-day old mice.
(J:193730)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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| Original: |
J:193730 Behesti H, et al., Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation. Dis Model Mech. 2013 Jan;6(1):49-63 |
| All: |
1 reference(s) |
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Analysis Tools
