Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Crb1em2Boc
Name:	crumbs family member 1, photoreceptor morphogenesis associated; endonuclease-mediated mutation 2, Bo Chang
MGI ID:	MGI:6259426
Gene:	Crb1  Location: Chr1:139124794-139304838 bp, - strand  Genetic Position: Chr1, 60.87 cM
Alliance:	Crb1em2Boc page

Strain of Origin:

B6.Cg-Crb1rd8 Jak3m1J/BocJ

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This TALEN-mediated mutation, generated in mice homozygous for the rd8 allele, is a 17 base pair intragenic deletion in exon 9 spanning nucleotides 3481-3497, which causes a frameshift with 7 amino acid substitutions before early termination. (J:265859) Inheritance:    Not Specified

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crb1 Mutation:	88 strains or lines available

Original:	J:265859 Chang B, et al., Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3, Is Dependent on the Crb1rd8 Allele. Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):5127-5139
All:	1 reference(s)