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Gene Expression Data
Assay Details
Assay
Reference: J:35171 Hofmann C, et al., Analysis of limb patterning in BMP-7-deficient mice. Dev Genet. 1996;19(1):43-50
Assay type: RNA in situ
MGI Accession ID: MGI:6203130
Gene symbol: Msx1
Gene name: msh homeobox 1
Probe: Msx-1 cDNA
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 3C left: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: forelimb digit epithelium Strong 3C left apical ectodermal ridge
TS20: hindlimb digit epithelium Strong 3C left apical ectodermal ridge
TS20: forelimb mesenchyme Strong Regionally restricted 3C left Expressed in the mesenchyme underlying the apical ectodermal ridge.
TS20: hindlimb mesenchyme Strong Regionally restricted 3C left Expressed in the mesenchyme underlying the apical ectodermal ridge.
Specimen 3C right: embryonic day 12.0; Bmp7tm1Kry/Bmp7tm1Kry (more )
Structure Level Pattern Image Note
TS20: forelimb digit epithelium Present 3C right apical ectodermal ridge
TS20: hindlimb digit epithelium Present 3C right apical ectodermal ridge
TS20: forelimb mesenchyme Present 3C right Reduced expression, particularly the mesenchymal expression in the progress zone is diminished.
TS20: hindlimb mesenchyme Present 3C right Reduced expression, particularly the mesenchymal expression in the progress zone is diminished.
Specimen 3D left: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forelimb digit epithelium Strong 3D left
TS20: forelimb interdigital region mesenchyme Strong 3D left
Specimen 3D right: embryonic day 12.5; Bmp7tm1Kry/Bmp7tm1Kry (more )
Structure Level Pattern Image Note
TS20: forelimb digit epithelium Strong 3D right
TS20: forelimb interdigital region mesenchyme Present 3D right Clearly reduced signal.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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