Tg(PAX6)4Vvh
Transgene Detail
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| Symbol: |
Tg(PAX6)4Vvh |
| Name: |
transgene insertion 4, Veronica van Heyningen |
| MGI ID: |
MGI:6203049 |
| Synonyms: |
Y589-4 |
| Transgene: |
Tg(PAX6)4Vvh Location: unknown
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| Alliance: |
Tg(PAX6)4Vvh page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(PAX6)4Vvh expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
PAX6 (5080) |
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human YAC |
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Mutation details: This transgene, comprising the 310 kb human chr 11 YAC Y589 (from ICI library), retrofitted with a conditional centromere, was microinjected into pronuclei of B6CBA embryos. The YAC spans 160 kb upstream and 150 kb downstream of PAX6 promoter P1, a region that includes the SGL but not the SIMO breakpoints associated with cases of familial aniridia. Four transgenic lines were established, with line 4 carying an upstream truncated copy of the YAC.
(J:265823)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:265823 Kleinjan DA, et al., Aniridia-associated translocations, DNase hypersensitivity, sequence comparison and transgenic analysis redefine the functional domain of PAX6. Hum Mol Genet. 2001 Sep 15;10(19):2049-59 |
| All: |
1 reference(s) |
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Analysis Tools
