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Tg(PAX6)4Vvh
Transgene Detail
Summary
Symbol: Tg(PAX6)4Vvh
Name: transgene insertion 4, Veronica van Heyningen
MGI ID: MGI:6203049
Synonyms: Y589-4
Transgene: Tg(PAX6)4Vvh  Location: unknown  
Alliance: Tg(PAX6)4Vvh page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(PAX6)4Vvh expresses 1 gene
 
Mutation detailsThis transgene, comprising the 310 kb human chr 11 YAC Y589 (from ICI library), retrofitted with a conditional centromere, was microinjected into pronuclei of B6CBA embryos. The YAC spans 160 kb upstream and 150 kb downstream of PAX6 promoter P1, a region that includes the SGL but not the SIMO breakpoints associated with cases of familial aniridia. Four transgenic lines were established, with line 4 carying an upstream truncated copy of the YAC. (J:265823)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:265823 Kleinjan DA, et al., Aniridia-associated translocations, DNase hypersensitivity, sequence comparison and transgenic analysis redefine the functional domain of PAX6. Hum Mol Genet. 2001 Sep 15;10(19):2049-59
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory