Tg(FSHB*)#Kmar
Transgene Detail
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| Symbol: |
Tg(FSHB*)#Kmar |
| Name: |
transgene insertion, T Rajendra Kumar |
| MGI ID: |
MGI:6202350 |
| Synonyms: |
HFSHB-LHB, HFSHBMut |
| Transgene: |
Tg(FSHB*)#Kmar Location: unknown
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| Alliance: |
Tg(FSHB*)#Kmar page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(FSHB*)#Kmar expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
FSHB (2488) |
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human gene, with C-terminal 7 codons of human LHB gene added to end of coding region |
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Mutation details: The transgene consists of the human gene, including promoter, contained within a 10 kb genomic fragment. The gene was modified through the addition of the last 21 bp of the human LHB (luteinizing hormone beta) gene to the end of the cioding region in exon 3. This sequence codes for a C-terminal heptapeptide that promotes secretion of the heterodimer (with this allele: Cga-FSHB) via the regulated pathway in heterologous somatotrope cells.
(J:208630)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:208630 Wang H, et al., Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5735-40 |
| All: |
1 reference(s) |
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Analysis Tools
