Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Ntsr2tm1.1(cre)Giml
Name:	neurotensin receptor 2; targeted mutation 1.1, Gina M Leinninger
MGI ID:	MGI:6202113
Synonyms:	NtsR2deltaNEO-Cre, NtsR2Dev
Gene:	Ntsr2  Location: Chr12:16703477-16710223 bp, + strand  Genetic Position: Chr12, 7.98 cM
Alliance:	Ntsr2tm1.1(cre)Giml page

Germline Transmission:	Earliest citation of germline transmission: J:263745
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Ntsr2tm1.1(cre)Giml expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ntsr2 (MGI:108018)   Mutation details: The targeting vector was generated by inserting an IRES-Cre between the stop codon and the polyadenylation site of the sequence encoding the 3' end of the mouse NtsR2 gene, with an FRT-flanked NEO cassette placed upstream of the IRES-Cre. Correctly recombined ES clones via homologous recombination were expanded, and injected into mouse blastocystes to generate chimeric males. Mice were bred to a FlpO deleter line to remove neo cessette to make constitutive cre expression throughout life. (J:263745)

Activity:	Tissue activity of this recombinase allele
Driver:	Ntsr2 (mouse) Summary of all recombinase alleles driven by Ntsr2. Comparative matrix view of recombinase activities Alliance mouse Ntsr2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntsr2 Mutation:	21 strains or lines available

Original:	J:263745 Woodworth HL, et al., Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan. eNeuro. 2018 Jan-Feb;5(1):ENEURO.0191-17.2018
All:	2 reference(s)