Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Ntsr1tm1(cre)Giml
Name:	neurotensin receptor 1; targeted mutation 1, Gina M Leinninger
MGI ID:	MGI:6202108
Synonyms:	NtsR1Adult, NtsR1NEO-Cre
Gene:	Ntsr1  Location: Chr2:180141769-180186772 bp, + strand  Genetic Position: Chr2, 103.04 cM, cytoband H1-H4
Alliance:	Ntsr1tm1(cre)Giml page

Germline Transmission:	Earliest citation of germline transmission: J:263745
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Recombinase) Mutation:    Insertion   Ntsr1tm1(cre)Giml expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ntsr1 (MGI:97386)   Mutation details: The targeting vector was generated by inserting an IRES-Cre between the stop codon and the polyadenylation site of the sequence encoding the 3' end of the mouse NtsR1 gene, with an frt-flanked NEO cassette placed upstream of the IRES-Cre. Correctly recombined ES clones via homologous recombination were expanded, and injected into mouse blastocystes to generate chimeric males. Presence of frt-flanked NEO cassette prevents cre expression until exposure to FlpO. (J:263745)

Activity:	Tissue activity of this recombinase allele
Driver:	Ntsr1 (mouse) Summary of all recombinase alleles driven by Ntsr1. Comparative matrix view of recombinase activities Alliance mouse Ntsr1 gene page
User Notes:	Additional information submitted by the research community Additional information submitted by the research community FlpO expression is required to remove FRT-flanked NEO cassette to induce cre expression. J:263745

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntsr1 Mutation:	31 strains or lines available

Original:	J:263745 Woodworth HL, et al., Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan. eNeuro. 2018 Jan-Feb;5(1):ENEURO.0191-17.2018
All:	1 reference(s)