Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Albem1(dre/ERT2)Bzsh
Name:	albumin; endonuclease-mediated mutation 1, Bin Zhou
MGI ID:	MGI:6202045
Synonyms:	Alb-DreER
Gene:	Alb  Location: Chr5:90608756-90624461 bp, + strand  Genetic Position: Chr5, 44.7 cM
Alliance:	Albem1(dre/ERT2)Bzsh page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Albem1(dre/ERT2)Bzsh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Alb (MGI:87991)   Mutation details: The line was generated by inserting a cDNA encoding IRES-Dre recombinase fused with a mutant form of estrogen receptor hormon-binding domaine C (ERT2) into in-frame with the translational termination codon of the last coding exon of Alb by homologous recombination using the CRISPR/Cas9 technology. This knock-in strategy leads to simultaneous expression of DreER and endogenous albumin. (J:263751)

Activity:	Tissue activity of this recombinase allele
Driver:	Alb (mouse) Summary of all recombinase alleles driven by Alb. Comparative matrix view of recombinase activities Alliance mouse Alb gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alb Mutation:	91 strains or lines available

Original:	J:263751 Wang Y, et al., Genetic tracing of hepatocytes in liver homeostasis, injury, and regeneration. J Biol Chem. 2017 May 26;292(21):8594-8604
All:	3 reference(s)