Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Grptm1.1(icre)Himo
Name:	gastrin releasing peptide; targeted mutation 1.1, Hisashi Mori
MGI ID:	MGI:6201709
Synonyms:	Grp-iCre
Gene:	Grp  Location: Chr18:66005891-66019667 bp, + strand  Genetic Position: Chr18, 38.98 cM
Alliance:	Grptm1.1(icre)Himo page

Germline Transmission:	Earliest citation of germline transmission: J:264153
Parent Cell Line:	RENKA (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Grptm1.1(icre)Himo expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Grp (MGI:95833)   Mutation details: iCre and FRT flanked pgk-neo cassettes were inserted into the gastrin-releasing peptide gene (Grp) locus translation initiation site by homologous recombination in ES cells. The chimeric mouse obtained was crossed with a CAG-FLPe mouse to delete the pgk-neo cassette and establish the mouse line. (J:264153)

Activity:	Tissue activity of this recombinase allele
Driver:	Grp (mouse) Summary of all recombinase alleles driven by Grp. Comparative matrix view of recombinase activities Alliance mouse Grp gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grp Mutation:	30 strains or lines available

Original:	J:264153 Inoue R, et al., Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress. Elife. 2018 Jun 26;7:e34135
All:	1 reference(s)