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Gene Expression Data
Assay Details
Assay
Reference: J:166085 Bott RC, et al., KDR-LacZ-expressing cells are involved in ovarian and testis-specific vascular development, suggesting a role for VEGFA in the regulation of this vasculature. Cell Tissue Res. 2010 Oct;342(1):117-30
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6201409
Gene symbol: Kdr
Gene name: kinase insert domain protein receptor
Reporter: lacZ
Direct Detection
Results
Specimen not shown: embryonic day 10.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS16: gonad primordium Absent
TS16: mesonephros Present Regionally restricted Staining was detected in the networks of vasculature within the mesonephros.
Specimen 1a: embryonic day 11.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS18: developing vasculature of genitourinary system Present Regionally restricted 1a Expression was located predominately within the vasculature of the mesonephros.
TS18: mesonephros Present Regionally restricted 1a Expression was located predominately within the vasculature of the mesonephros.
TS18: gonad primordium Present Single cells 1a
Specimen 1b: embryonic day 11.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS18: developing vasculature of genitourinary system Present Regionally restricted 1b Expression was located predominately within the vasculature of the mesonephros.
TS18: mesonephros Present Regionally restricted 1b Expression was located predominately within the vasculature of the mesonephros.
TS18: gonad primordium Present 1b
Specimen 1c: embryonic day 12.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: developing vasculature of male mesonephros Present 1c
TS20: developing vasculature of testis Present 1c No differences were apparent in staining between the testis and ovary at E12.0.
Specimen 1d: embryonic day 12.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: developing vasculature of female mesonephros Present 1d
TS20: developing vasculature of ovary Present 1d No differences were apparent in staining between the testis and ovary at E12.0.
Specimen 1e: embryonic day 12.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: developing vasculature of male mesonephros Present 1e
TS20: developing vasculature of testis Present 1e The vascular pattern appeared different in the testis, with vasculature surrounding the seminiferous cords and a distinct coelomic vessel, compared to the ovary.
TS20: coelomic vessel Present 1e
Specimen 1f: embryonic day 12.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: developing vasculature of female mesonephros Present 1f
TS20: developing vasculature of ovary Present 1f
Specimen 1g: embryonic day 13.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS21: coelomic vessel Present 1g
TS21: developing vasculature of male mesonephros Present 1g
TS21: developing vasculature of testis Present 1g
Specimen 1h: embryonic day 13.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS21: developing vasculature of female mesonephros Present 1h The vasculature within the ovary and mesonephros of the E13 female was much more densely organized than in the male.
TS21: developing vasculature of ovary Present 1h The vasculature within the ovary and mesonephros of the E13 female was much more densely organized than in the male.
Specimen 2a: embryonic day 11.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: testis Present Regionally restricted 2a Staining was detected in small populations of cells in close proximity to the mesonephros.
TS20: mesonephros of male Present 2a An abundance of expressing cells was present throughout the mesonephros.
Specimen 2b: embryonic day 11.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: developing vasculature of female mesonephros Present 2b
Specimen 2c: embryonic day 11.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: testis Present Regionally restricted 2c Staining was detected in small populations of cells in close proximity to the mesonephros.
TS20: mesonephros of male Present 2c An abundance of expressing cells was present throughout the mesonephros.
Specimen 2d: embryonic day 11.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: developing vasculature of female mesonephros Present 2d
Specimen 2e: embryonic day 12.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: coelomic vessel Present 2e
TS20: testis Present Regionally restricted 2e Expressing cells surrounded the seminiferous cords.
Specimen 2f: embryonic day 12.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: developing vasculature of ovary Present 2f
Specimen 2g: embryonic day 12.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: coelomic vessel Present 2g
TS20: testis Present Regionally restricted 2g Expressing cells surrounded the seminiferous cords.
Specimen 2h: embryonic day 12.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS20: developing vasculature of ovary Present 2h
Specimen 2i: embryonic day 13.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS21: coelomic vessel Present 2i
TS21: interstitium of the testis Present Regionally restricted 2i Expressing cells surrounded the seminiferous cords.
Specimen 2j: embryonic day 13.5; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS21: ovary Present 2j Staining was present throughout the ovary.
Specimen 5a: embryonic day 16.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS24: coelomic vessel Present 5a
TS24: developing vasculature system of epididymis Present 5a
TS24: developing vasculature of testis Present 5a Expression was detected in the vasculature surrounding the seminiferous cords.
Specimen 5b: embryonic day 16.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS24: developing vasculature of ovary Present 5b
Specimen 5c: postnatal day 0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS27: coelomic vessel Present 5c
TS27: developing vasculature of testis Present 5c
TS27: developing vasculature system of epididymis Present 5c
Specimen 5d: postnatal day 0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS27: developing vasculature of ovary Present 5d
TS27: developing vasculature of oviduct Present 5d
Specimen 5e: postnatal day 3; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS27: coelomic vessel Present 5e
TS27: developing vasculature of testis Present 5e
Specimen 5f: postnatal day 3; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS27: developing vasculature of ovary Present 5f
Specimen not shown: embryonic day 16.0; Kdrtm1Jrt/Kdr+ (more )
Structure Cell Type Level Pattern Image Note
TS24: germ cell of testis Present Expression was detected in Sertoli cells and early stage germ cells within the seminiferous cords in approximately 50% of E16.0 males.
TS24: seminiferous cord Present Expression was detected in Sertoli cells and early stage germ cells within the seminiferous cords in approximately 50% of E16.0 males.
TS24: Sertoli cell Sertoli cell Present Expression was detected in Sertoli cells and early stage germ cells within the seminiferous cords in approximately 50% of E16.0 males.
Specimen 6a: embryonic day 17.0; Kdrtm1Jrt/Kdr+ (more )
Structure Cell Type Level Pattern Image Note
TS25: interstitium of the testis Strong Regionally restricted 6a Stained cells were located throughout the interstitium. Intense expression was detected in the interstitium surrounding the seminiferous cords.
TS25: germ cell of testis Present 6a Expression was detected in Sertoli cells and early stage germ cells within the seminiferous cords in approximately 70% of E17.0 males.
TS25: seminiferous cord Present 6a Expression was detected in Sertoli cells and early stage germ cells within the seminiferous cords in approximately 70% of E17.0 males.
TS25: Sertoli cell Sertoli cell Present 6a
Specimen not shown: embryonic day 17.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS25: mesonephros Weak
Specimen 6b: postnatal day 0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS27: interstitium of the testis Strong 6b
Specimen not shown: postnatal day 3; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS27: interstitium of the testis Strong
Specimen not shown: postnatal day 4; Kdrtm1Jrt/Kdr+ (more )
Structure Cell Type Level Pattern Image Note
TS28: seminiferous cord Present
TS28: germ cell of testis Present Small numbers of Sertoli cells and gonocytes were stained.
TS28: Sertoli cell Sertoli cell Present Small numbers of Sertoli cells and gonocytes were stained.
Specimen 6c: postnatal day 20; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS28: spermatid Present 6c Expression was located in round spermatids.
Specimen not shown: postnatal day 30; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS28: spermatid Present Expression was detected in round spermatids.
Specimen 6d: postnatal day 60; Kdrtm1Jrt/Kdr+ (more )
Structure Cell Type Level Pattern Image Note
TS28: spermatid Present 6d Expression was detected in round, elongating, and elongated spermatids.
TS28: seminiferous tubule Present 6d
TS28: Sertoli cell Sertoli cell Present 6d
Specimen 7a: embryonic day 17.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS25: mesonephros Strong Regionally restricted 7a Expression was detected in mesonephric vessels.
TS25: oviduct Present 7a
TS25: ovary Present Regionally restricted 7a Expression was prominent in the medulla and between oocyte cysts in the cortex.
TS25: oocyte Weak 7a Faint staining was detected on oocytes within the oocyte cysts.
Specimen 7b: embryonic day 17.0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS25: ovary Present Regionally restricted 7b Expression was prominent in the medulla and between oocyte cysts in the cortex.
TS25: oocyte Weak 7b Faint staining was detected on oocytes within the oocyte cysts.
Specimen 7c: postnatal day 0; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS27: ovary Present Regionally restricted 7c Staining was noted surrounding primordial and primary follicles.
Specimen not shown: postnatal day 3; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS27: ovary Present Regionally restricted Staining was noted surrounding primordial and primary follicles.
Specimen 7d: postnatal day 15; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS28: ovary Present Regionally restricted 7d Expression was abundant in theca and interstitial cells.
TS28: mesenchymal stroma of ovary Present Regionally restricted 7d Expression was detected in interstitial cells.
TS28: ovary theca Present 7d
TS28: oocyte of secondary follicle Weak 7d
TS28: ovary stratum granulosum Weak 7d
Specimen 7e: postnatal day 30; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS28: oocyte of secondary follicle Weak 7e
TS28: ovary stratum granulosum Weak 7e
TS28: ovary theca Present 7e
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory