Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Hcrttm1.1(cre)Ldl
Name:	hypocretin; targeted mutation 1, Luis de Lecea
MGI ID:	MGI:6201351
Synonyms:	Hcrt-Cre, Hcrt-IRES-Cre
Gene:	Hcrt  Location: Chr11:100652519-100653757 bp, - strand  Genetic Position: Chr11, 63.6 cM
Alliance:	Hcrttm1.1(cre)Ldl page

Germline Transmission:	Earliest citation of germline transmission: J:264534
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Hcrttm1.1(cre)Ldl expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Hcrt (MGI:1202306)   Mutation details: Bacterial artificial chromosome clones containing the preprohypocretin (Hcrt) gene were used to target a cassette containing the internal ribosomal entry sequence (IRES) linked to Cre recombinase and a Frt-flanked neomycin resistance gene immediately downstream of the exon 2 stop codon. The target construct was electroporated into C57BL/6 embryonic stem cells, targeted clones were injected into blastocysts, and resultantchimeras were bred for germline transmission and then crossed with Flp-deletion mice to remove the neomycin selection gene. (J:264534)

Activity:	Tissue activity of this recombinase allele
Driver:	Hcrt (mouse) Summary of all recombinase alleles driven by Hcrt. Comparative matrix view of recombinase activities Alliance mouse Hcrt gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcrt Mutation:	19 strains or lines available

Original:	J:264534 Giardino WJ, et al., Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states. Nat Neurosci. 2018 Aug;21(8):1084-1095
All:	6 reference(s)