Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Ntrk2-cre/ERT2)#Phep
Name:	transgene insertion, Paul A Heppenstall
MGI ID:	MGI:6201344
Synonyms:	TrkBCreERT2
Transgene:	Tg(Ntrk2-cre/ERT2)#Phep  Location: unknown
Alliance:	Tg(Ntrk2-cre/ERT2)#Phep page

Strain of Origin:

(C57BL/6 x DBA/2)F1

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Ntrk2-cre/ERT2)#Phep expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Ntrk2 (MGI:97384)   Mutation details: A cassette containing a modified CreERT2-pA-Frt-Ampicillin-Frt was inserted in the first coding ATG of exon 2 into a bacterial artificial chromosome (BAC) containing the Ntrk2 mouse locus (RP23-391J8) deleting the entire coding region of exon 2. Purified BAC cDNA was purified and injected into pronuclei of B6D2F1/N oocytes or prepared for intracytoplasmic sperm injection (ICSI). Both methods produced transgenic offspring. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:265202)

Activity:	Tissue activity of this recombinase allele
Driver:	Ntrk2 (mouse) Summary of all recombinase alleles driven by Ntrk2. Alliance mouse Ntrk2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:265202 Dhandapani R, et al., Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons. Nat Commun. 2018 Apr 24;9(1):1640
All:	1 reference(s)