About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:81010 McBurney MW, et al., The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol. 2003 Jan;23(1):38-54
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6201274
Gene symbol: Sirt1
Gene name: sirtuin 1
Results
Specimen 11A/C: embryonic day 1.0 (more )
Structure Level Pattern Image Note
TS2: 2-cell stage embryo Present Regionally restricted 11A , 11C Expression is exclusively nucles, excluded from regions of chromatin.
TS2: polar body Absent 11A , 11C Authors report expression is excluded from the two polar bodies.
Specimen 12A/C: postnatal adult (more )
Structure Level Pattern Image Note
TS28: ovary stratum granulosum Strong Regionally restricted 12A , 12C High levels of expression in proliferating granulosa cells.
Specimen 12D/F: postnatal adult (more )
Structure Level Pattern Image Note
TS28: ovary stratum granulosum Strong Regionally restricted 12D , 12F Expression is nuclear, but appears to be excluded from nucleolus.
Specimen 13A: postnatal adult (more )
Structure Level Pattern Image Note
TS28: germ cell of testis Present Regionally restricted 13A Various extent of expression in immature spermatogenic cells. Authors report no expression in elongate spermatocyte stage.
TS28: testis Present Regionally restricted 13A No expression in somatic cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory