Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Ly6atm1.1(cre)Jmol
Name:	lymphocyte antigen 6 family member A; targeted mutation 1.1, Jeffery D Molkentin
MGI ID:	MGI:6198589
Synonyms:	Ly6aCre
Gene:	Ly6a  Location: Chr15:74866726-74869880 bp, - strand  Genetic Position: Chr15, 34.29 cM
Alliance:	Ly6atm1.1(cre)Jmol page

Germline Transmission:	Earliest citation of germline transmission: J:264764
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Recombinase) Mutation:    Insertion   Ly6atm1.1(cre)Jmol expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ly6a (MGI:107527)   Mutation details: A cDNA encoding cre-IRES-EGFPnls (nuclear localized EGFP) as well as an FRT-flanked neomycin cassette was recombined in-frame with the Ly6a ATG start codon (exon 2) via homologous recombination. Resultant mice were crossed with Flpe mice to delete the neomycin cassette. Though present in the targeting construct, IRES-driven expression of EGFPnls is not observed. Expression of Ly6a is eliminated by the targeted allele. (J:264764)

Activity:	Tissue activity of this recombinase allele
Driver:	Ly6a (mouse) Summary of all recombinase alleles driven by Ly6a. Comparative matrix view of recombinase activities Alliance mouse Ly6a gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ly6a Mutation:	20 strains or lines available

Original:	J:264764 Vagnozzi RJ, et al., Genetic Lineage Tracing of Sca-1(+) Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Circulation. 2018 Jul 10;
All:	1 reference(s)