Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Cmahem1Guru
Name:	cytidine monophospho-N-acetylneuraminic acid hydroxylase; endonuclease-mediated mutation 1, Channabasavaiah Gurumurthy
MGI ID:	MGI:6198533
Synonyms:	cmah-
Gene:	Cmah  Location: Chr13:24511387-24661272 bp, + strand  Genetic Position: Chr13, 10.34 cM, cytoband A3.2
Alliance:	Cmahem1Guru page

Strain of Origin:

NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: CRISPR/cas9 endonuclease mediated genome editing is used to introduce a 27 bp deletion in the target site (one nucleotide in intron 5-6 and the remaining 26 nucleotides in exon 6) on chromosome 13. (J:268694)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cmah Mutation:	37 strains or lines available

Original:	J:268694 Dagur RS, et al., Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection. BMC Immunol. 2019 Jan 7;20(1):2
All:	1 reference(s)