Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Tyr-MC1R)R151CRucu
Name:	transgene insertion R151C, Rutao Cui
MGI ID:	MGI:6196889
Synonyms:	Mc1rR151C, MC1R(R151C)
Transgene:	Tg(Tyr-MC1R)R151CRucu  Location: unknown
Alliance:	Tg(Tyr-MC1R)R151CRucu page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Tyr-MC1R)R151CRucu expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human MC1R (4157) Mc1r  (MGI:99456) mouse promoter and human red hair colour variant gene   Mutation details: The gene for a red hair colour (RHC) variant (p.Arg151Cys or p.R151C) of human melanocortin 1 receptor was placed downstream of the mouse tyrosinase enhancer/promoter. Bovine growth hormone poly(A) signal sequences were placed downstream of the human gene. The transgene construct was microinjected into zygotes derived from Mc1r knockout mice containing the Mc1re allele. (J:252840)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:252840 Chen S, et al., Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Nature. 2017 Sep 21;549(7672):399-403
All:	2 reference(s)