Tg(Omp-Ncam2)TmSbo
Transgene Detail
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| Symbol: |
Tg(Omp-Ncam2)TmSbo |
| Name: |
transgene insertion Tm, Staffan Bohm |
| MGI ID: |
MGI:6196080 |
| Synonyms: |
OMP-TmRNCAM |
| Transgene: |
Tg(Omp-Ncam2)TmSbo Location: unknown
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| Alliance: |
Tg(Omp-Ncam2)TmSbo page
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| Strain of Origin: |
C57BL/6 x CBA
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Omp-Ncam2)TmSbo expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Ncam2 (MGI:97282) |
mouse promoter and gene, transmembrane domain-containing isoform |
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Mutation details: A 6 kb promoter-containing region upstream of the translation start codon of the olfactory marker protein gene was used to drive the over- or ectopic expression of the neural cell adhesion molecule 2 gene in olfactory sensory neurons (OSNs). The gene sequence consists of the coding part of the cDNA, where the last 354 bp of sequence (coding region plus 78 bp of 3' UTR) unique to the glycosyl-phosphatidylinositol (Gpi) anchor-containing isoform was replaced with 538 bp of 3' coding sequence plus 268 bp of 3' UTR unique to the transmembrane isoform, followed by SV40 poly(A) signal sequence. This transgene overexpresses the gene in OSNs in olfactory receptor zones 2-4 (Z2-4) and ectopically expresses in Z1.
(J:81623)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:81623 Alenius M, et al., Differential function of RNCAM isoforms in precise target selection of olfactory sensory neurons. Development. 2003 Mar;130(5):917-27 |
| All: |
1 reference(s) |
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Analysis Tools
