Ighg1em1Durw
Endonuclease-mediated Allele Detail
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| Symbol: |
Ighg1em1Durw |
| Name: |
immunoglobulin heavy constant gamma 1 (G1m marker); endonuclease-mediated mutation 1, Duane R Wesemann |
| MGI ID: |
MGI:6195842 |
| Gene: |
Ighg1 Location: Chr12:113290161-113294143 bp, - strand Genetic Position: Chr12, 62.1 cM
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| Alliance: |
Ighg1em1Durw page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:252910
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| Parent Cell Line: |
TC1/TC-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Endonuclease-mediated (Not Specified) |
| Mutation: |
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Intragenic deletion
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Mutation details: With sgRNAs targeting the mu and gamma1 switch regions in the Igh-C immunoglobulin heavy chain constant region, the intervening sequence was deleted in ES cells using CRISPR/Cas9 technology. This engineered recombination (deleting the Ighm, Ighd, and Ighg3 segments) mimics an IgG1 class-switch.
(J:252910)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ighg1 Mutation: |
28 strains or lines available
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| Original: |
J:252910 Tong P, et al., IgH isotype-specific B cell receptor expression influences B cell fate. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8411-E8420 |
| All: |
1 reference(s) |
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Analysis Tools
