Gene Expression Data
Assay Details
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Assay
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Reference:
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J:141989
Kirjavainen A, et al., Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. Dev Biol. 2008 Oct 1;322(1):33-45
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:6195804
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Gene symbol:
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Prox1
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Gene name:
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prospero homeobox 1
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Results
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Specimen
E14.5 not shown:
embryonic day 14.5
(more  )
Specimen
E14.5 not shown:
(close  )
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Genetic Background:
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NMRI
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: cochlea |
Absent |
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No expression in presumptive organ of Corti at E14.5 or earlier stages.
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Specimen
1A:
embryonic day 15.0
(more )
Specimen
1A:
(close )
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Genetic Background:
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NMRI
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Age:
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embryonic day 15.0
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: cochlea |
Present |
Regionally restricted |
1A
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Expression first detected in basal coil of cochlea. Strong expression in region of future outer hair cells. Weak expression in non-sensory supporting cells of both sides of the future organ of Corti. No expression in inner hair cells.
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Specimen
1D:
embryonic day 15.5
(more )
Specimen
1D:
(close )
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Genetic Background:
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NMRI
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: cochlea |
Weak |
Regionally restricted |
1D
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Strong expression maintained in Deiters cells and pillar cells. Decreased expression in outer hair cells. Weak expression in non-sensory supporting cells, including inner phalangeal cells located underneath inner hair cells, as well as Hensen cells and Claudius cells on lateral side of organ of Corti.
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Specimen
1G:
postnatal day 0
(more )
Specimen
1G:
(close )
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Genetic Background:
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NMRI
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Age:
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postnatal day 0
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS27: organ of Corti |
Present |
Regionally restricted |
1G
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Strong expression in Deiters cells and pillar cells. Expression in outer hair cells of basal coil. Weaker expression in Hensen and Claudius cells.
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Specimen
P1 cochlea not shown:
postnatal day 1
(more )
Specimen
P1 cochlea not shown:
(close )
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Genetic Background:
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NMRI
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Age:
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postnatal day 1
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS27: cochlea |
Present |
Regionally restricted |
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Expression in outer hair cells of basal coil.
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Specimen
1J:
postnatal day 7
(more )
Specimen
1J:
(close )
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Genetic Background:
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NMRI
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Age:
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postnatal day 7
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: organ of Corti |
Present |
Regionally restricted |
1J
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No expression in outer hair cells of basal coil. Expression restricted to Deiters cells and pillar cells, most strongly in outer pillar cells and lateral-most Deiters cells.
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Specimen
1K:
postnatal day 25
(more )
Specimen
1K:
(close )
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Genetic Background:
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NMRI
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Age:
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postnatal day 25
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: organ of Corti |
Present |
Regionally restricted |
1K
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Expression restricted to Deiters cells and pillar cells, most strongly in outer pillar cells and lateral-most Deiters cells.
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Specimen
1L:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Gfi1tm2Tmo/Gfi1tm2Tmo
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: cochlea |
Present |
Regionally restricted |
1L
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Authors report expression in inner ear sensory epithelia was unaltered in Gfi1 mutant mice.
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Specimen
1M:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Gfi1tm2Tmo/Gfi1tm2Tmo
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Age:
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postnatal day 0
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS27: organ of Corti |
Present |
Regionally restricted |
1M
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Authors report expression in inner ear sensory epithelia was unaltered in Gfi1 mutant mice.
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Specimen
2A:
embryonic day 13.5
(more )
Specimen
2A:
(close )
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Genetic Background:
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NMRI
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: utricle |
Present |
Regionally restricted |
2A
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Expression in supporting cells. No expression in hair cells.
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Specimen
2B:
embryonic day 15.0
(more )
Specimen
2B:
(close )
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Genetic Background:
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NMRI
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Age:
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embryonic day 15.0
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: utricle |
Present |
Regionally restricted |
2B
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Expression confined to supporting cells. No expression in hair cells.
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Specimen
2C:
postnatal day 0
(more )
Specimen
2C:
(close )
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Genetic Background:
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NMRI
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Age:
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postnatal day 0
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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|
Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS27: utricle |
Present |
Regionally restricted |
2C
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Expression maintained in supporting cells. No expression in hair cells.
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Specimen
P1 utricle not shown:
postnatal day 1
(more )
Specimen
P1 utricle not shown:
(close )
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Genetic Background:
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NMRI
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Age:
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postnatal day 1
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS27: utricle |
Present |
Regionally restricted |
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Expression maintained in supporting cells. No expression in hair cells.
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Specimen
6B:
(close )
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Genetic Background:
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involves: 129S6/SvEvTac
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Mutant Allele(s):
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Fgfr3tm1Dor/Fgfr3tm1Dor
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: cochlea |
Present |
Regionally restricted |
6B
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Expression in outer hair cells and supporting cells appears unaltered compared to wild type.
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