Tg(Acta2-PTHLH)375Clem
Transgene Detail
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| Symbol: |
Tg(Acta2-PTHLH)375Clem |
| Name: |
transgene insertion 375, Thomas L Clemens |
| MGI ID: |
MGI:6195628 |
| Synonyms: |
SMP8-PTHrP |
| Transgene: |
Tg(Acta2-PTHLH)375Clem Location: unknown
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| Alliance: |
Tg(Acta2-PTHLH)375Clem page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Acta2-PTHLH)375Clem expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
PTHLH (5744) |
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mouse promoter and human gene |
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Mutation details: a 3.6-kb fragment of the mouse smooth muscle alpha actin gene (SMP8) containing 1074 bp of the upstream (promoter) region, the 63 bp exon 1 (5' UTR), the 2.5 kb first intron, and 15 bp of exon 2 5' UTR), was used to drive the expression of the human parathyroid hormone-like peptide cDNA sequence. SV40 poly(A) signal sequences (240 bp) are placed downstream of the cDNA. Northern blot experiments showed very high levels in bladder, stomach, uterus, and aorta and to lower expression in intestine. In situ hybridization showed that the expression was restricted to smooth muscle, including the smooth muscle cell layers of the intestine, aorta, bladder, stomach, bronchus, pulmonary artery, uterus, and meningeal and renal arterioles.
(J:54258)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:54258 Maeda S, et al., Targeted overexpression of parathyroid hormone-related protein (PTHrP) to vascular smooth muscle in transgenic mice lowers blood pressure and alters vascular contractility [see comments]. Endocrinology. 1999 Apr;140(4):1815-25 |
| All: |
1 reference(s) |
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Analysis Tools
