Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gli2tm1(cre/ERT2)Tipe
Name:	GLI-Kruppel family member GLI2; targeted mutation 1, Tien Peng
MGI ID:	MGI:6195610
Synonyms:	Gli2creERT2-tdT
Gene:	Gli2  Location: Chr1:118761862-118981349 bp, - strand  Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
Alliance:	Gli2tm1(cre/ERT2)Tipe page

Germline Transmission:	Earliest citation of germline transmission: J:264185
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Gli2tm1(cre/ERT2)Tipe expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gli2 (MGI:95728)   Mutation details: The allele was generated by inserting a CreERT2-2A-tdTomato expression cassette into the ATG site in exon2 of the Gli2 locus. (J:264185)

Activity:	Tissue activity of this recombinase allele
Driver:	Gli2 (mouse) Summary of all recombinase alleles driven by Gli2. Comparative matrix view of recombinase activities Alliance mouse Gli2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gli2 Mutation:	169 strains or lines available

Original:	J:264185 Wang C, et al., Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 Oct 1;128(10):4343-4358
All:	1 reference(s)