Tg(SLC10A1)39Mvw
Transgene Detail
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| Symbol: |
Tg(SLC10A1)39Mvw |
| Name: |
transgene insertion 39, Micheal Wiles |
| MGI ID: |
MGI:5883446 |
| Synonyms: |
hNTCP/BAC |
| Transgene: |
Tg(SLC10A1)39Mvw Location: unknown
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| Alliance: |
Tg(SLC10A1)39Mvw page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(SLC10A1)39Mvw expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
SLC10A1 (6554) |
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Mutation details: BAC RP11-72J8 was modified to include a 982bp synthetic gene that includes 500 bp of ROSA26 sequence to allow in vivo linearization by the CRISPR/Cas9 complex. Specifically, the gene contains from 5' to 3': human SLC10A1 sequence, an FRT-flanked PGK-Neo cassette, 500 bp of ROSA26 sequence and human SLC10A1 sequence (SLC10A1 sequence totals 397 bp).
Sequence analysis indicates that the ROSA26 sequence is 76,428 bp upstream of exon 1 of the SLC10A1 gene. Single guide RNAs are designed to target the ROSA26 locus and the RP11-72J8 BAC.
(J:263861)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:263861 Winer BY, et al., Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med. 2018 Jun 27;10(447) |
| All: |
1 reference(s) |
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Analysis Tools
