Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Esr1-rtTA)1Blpn
Name:	transgene insertion 1, Cedric Blanpain
MGI ID:	MGI:6194209
Synonyms:	ER-rtTA
Transgene:	Tg(Esr1-rtTA)1Blpn  Location: unknown
Alliance:	Tg(Esr1-rtTA)1Blpn page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Transactivator) Mutation:    Insertion   Mutation details: The transgene comprises the following elements: The mouse estrogen receptor 1 alpha promoter (4 kb genomic sequence upstream of ATG translation start), beta globin intron 1, the rtTA (reverse tetracycline-controlled transactivator) gene and SV40 poly(A) signal. This is part of the Tet-On system where mice double-transgenic for this transgene and a second transgene controlled by the tetO promoter express the second transgene in cells where the promoter of the first transgene is active when administered doxycycline. (J:254282)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:254282 Van Keymeulen A, et al., Lineage-Restricted Mammary Stem Cells Sustain the Development, Homeostasis, and Regeneration of the Estrogen Receptor Positive Lineage. Cell Rep. 2017 Aug 15;20(7):1525-1532
All:	1 reference(s)